76. Progesterone receptor expression is modulated by prostaglandins in human myometrial cells
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چکیده
منابع مشابه
Progesterone Acts via the Nuclear Glucocorticoid Receptor to Suppress IL-1β-Induced COX-2 Expression in Human Term Myometrial Cells
Progesterone is widely used to prolong gestation in women at risk of preterm labour (PTL), and acts at least in part via the inhibition of inflammatory cytokine-induced prostaglandin synthesis. This study investigates the mechanisms responsible for this inhibition in human myometrial cells. We used reporter constructs to demonstrate that interleukin 1beta (IL-1β) inhibits progesterone driven PR...
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Background: Infertility is defined as inability to achive pregnancy after one year of unprotected regular intercourse.it has been reported that about 10-15% of young couples suffer from infertility. There is evidence that antioxidants improve the fertility rate. Prunus cerasus contains strong antioxidant activity. The aim of this study is to evaluate Prunus cerasus effects on expression of prog...
متن کاملExpression of progesterone receptor in human keratinocytes.
Despite the various responses of human skin to female sex hormones, cellular and subcellular targets and the mechanisms of action of estrogen and progesterone in human skin are not well understood. The detection of estrogen receptor (ER) and progesterone receptor (PR) in the skin is of great importance to understand the effect of estrogen and progesterone. In primary cultures of human keratinoc...
متن کاملProgesterone receptor expression in the human placenta.
The presence of progesterone receptors (PR) in the human placenta has been demonstrated using the reverse transcriptase-polymerase chain reaction technique. It was observed that the amount of PR in the human placenta is less during late gestation. Electrophoretic mobility shift assays with nuclear extract isolated from the first trimester and term revealed three complexes when incubated with [3...
متن کاملProgesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-kappaB activation of cyclooxygenase 2 expression.
Spontaneous labor in women and in other mammals is likely mediated by a concerted series of biochemical events that negatively impact the ability of the progesterone receptor (PR) to regulate target genes that maintain myometrial quiescence. In the present study, we tested the hypothesis that progesterone/PR inhibits uterine contractility by blocking nuclear factor kappaB (NF-kappaB) activation...
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ژورنال
عنوان ژورنال: Reproduction, Fertility and Development
سال: 2003
ISSN: 1031-3613
DOI: 10.1071/srb03ab76